Micro and Small Enterprises (MSEs) have been widely recognized for playing significant role in poverty reduction through income generation from sales, job creation at low cost, utilization of locally found resources to add value to agriculture produce, and production of goods and services that meet basic needs of the poor. However, the contribution of MSEs to poverty reduction processes and development in general is much dependent on the length of period these enterprises survive. This study determined the survival chances of MSEs and analyzed the impact of liquidity constraints, owner characteristics, enterprise characteristics and business environmental factors on survival chances of off-farm MSEs at any time period using Cox Proportional Hazard model. The results indicate that the survival chance of MSEs declines quickly in the first 5 years after inception. Enterprises that have operated for 5 years continuously have a survival chance of 0.5837. In addition, the results shows that initial capital invested, family size of proprietor, completion of primary school level, business training and the street vendor relocation programme significantly reduce the chances of closing an enterprise at any time. In general, proprietor characteristics have a significant impact on enterprises survival. The policy implications are that measures should be put in place that will enhance access to credit to boast capital of small enterprises, promote business and vocational training for small entrepreneurs, and ensure that there are enough market infrastructures such that small enterprises operate from a designated market places.