This study investigated the barriers that prevent the Micro and Small Enterprises (MSEs) start up and hamper their potential growth in Malawi. The study further analysed the role of Youth Enterprise Development Fund (YEDF) on the growth of MSEs in Mwanza, Lilongwe Rural and Karonga districts. The study contributes to knowledge and literature of the YEDF on the growth of MSEs in Malawi. The study also provides a framework to policy makers on good administration and management of the Youth Enterprise Development Fund. Using both quantitative and qualitative approach the study findings indicate that the Fund has a long way to go to achieve MSEs growth. The study reveals that there has been little contribution of the fund to youth enterprises’ growth. Among other recommendations, the study the need to intensify awareness of the fund, entrepreneurial training to the youth and access to markets.