Job satisfaction has been a popular topic for researchers because it relates to several significant variables. As the ultimate goal in the education sector is service delivery, it is imperative that teachers perform optimally and maintain acceptable levels of job satisfaction in order to provide better education to the students of Malawi. However, literature is awash with so much controversy on the levels of satisfaction between urban and rural teachers. While others postulate that urban teachers are more satisfied than the rural, other studies have found the inverse. It was therefore, the purpose of this study to compare job satisfaction and its determinants between the urban and rural public secondary school teachers. The study followed the quantitative approach and used the Demographic, the Job Descriptive Index (JDI) and the Job In General (JIG) questionnaires to collect data from the teachers. Stratified proportional random sampling procedure was used. Descriptive and inferential statistics were used to analyse the data using SPSS16.0. Results show that there is no difference in job satisfaction between teachers in the urban and those in the rural public secondary schools. It has further been found that co-workers and the work itself are the main determinants of job satisfaction for both the rural and the urban teachers. Furthermore the study has found that tenure is another determinant of job satisfaction among the rural teachers while educational qualification determines teachers' job satisfaction in the urban. This study has further found that both co-workers and work itself are more powerful predictors of job satisfaction in the rural than they are in the urban.